The England defender was withdrawn at half-time in Sunday’s 6-3 Manchester derby win against United at the Etihad with a muscle problem and did not take part in training, meaning he is out for the visit of Danish opposition in Europe.
Midfielder Rhodri returns to the bench against Copenhagen, but Walker’s Three Lions team-mates John Stones and Calvin Phillips are still out.
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“We’ll train this afternoon and we’ll know exactly,” Pep Guardiola said of the latest City squad news at his pre-match press conference on Tuesday.
“Rhodri is feeling better, but Kyle I think is out.” But we have training later.
Asked if Phillips could be available ahead of the World Cup, Guardiola added: “I hope so. I hope for him and the national team. But I’m not a physical therapist – my doctor said I’m doing fine.
Ruben Diaz was only fit enough to make the bench against United but starts here alongside Aymeric Laporte after playing his first few minutes of the season following knee surgery in the summer.
Given City’s strong position in Group G, rotation may be in order, especially with a trip to Liverpool in the Premier League looming.
Guardiola has already confirmed that Erling Haaland will need to be rested at times, but he played down that tonight.
Manchester City in the starting lineup against FC Copenhagen (4-3-3): Ederson; Cancelo, Diaz, Laporte, Gomez; Gundogan, Grealish, Silva; Mahrez, Alvarez, Haaland